CHARACTERIZATION OF B CELLS IN LUPUS ERYTHEMATOSUS SKIN BIOPSIES IN THE CONTEXT OF DIFFERENT IMMUNE CELL INFILTRATION PATTERNS

Characterization of B cells in lupus erythematosus skin biopsies in the context of different immune cell infiltration patterns

Cutaneous lesions in lupus erythematosus (LE) subtypes are heterogenous.In line with the heterogeneity of the clinical Tie-Die presentation, the underlying lesional inflammation in LE skin samples is defined by different immune cell infiltrates.Pathophysiologically, lesional inflammation is driven by autoreactive cytotoxic T cells, targeting kerati

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Evaluation of the relation between T-Lymphocytes (CD4 + ve and CD8 + ve) and pemphigus vulgaris pathogenesis and severity

Background: Pemphigus vulgaris (PV) is an autoimmune bullous disease involving both the skin and mucus membranes.Infiltrating CD4+ and CD8+ T-lymphocytes may have a vital role in its pathogenesis.The autoimmune bullous skin disorder intensity score (ABSIS) was proposed for clinical evaluation and scoring of PV patients.Aims and Objectives: This wor

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